Submit Manuscript  

Article Details


Applications of Ammonium Bifluoride in Organic Synthesis

[ Vol. 22 , Issue. 6 ]

Author(s):

Jia-Sheng Li, Wei-Zhe Dong, Hui Lu and Fu-Min Zhang*   Pages 581 - 589 ( 9 )

Abstract:


Background: Ammonium bifluoride is a reagent widely used in organic synthesis; however, the systematic collection and classification have not been covered until now.

Methodology: In this review, we aim to systematically summarize the application of ammonium bifluoride in organic synthesis.

Conclusion: It can be used for deprotection of hydroxyl protected groups (esp. Silyl protection). It is also used for introducing F & N atoms into organic molecules; promoting cyclization reactions acting as a multifunctional reagent.

Keywords:

Ammonium bifluoride, removal of hydroxyl protecting groups, fluoride source, nitrogen source, cyclization, multifunction reagent, organic synthesis.

Affiliation:

State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, 730000, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, 730000, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, 730000, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, 730000

Graphical Abstract:



Read Full-Text article