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Microwave Assisted Synthesis of Spiro Heterocyclic Systems: A Review

[ Vol. 22 , Issue. 1 ]


Pankaj Khanna, Leena Khanna, Sean J. Thomas, Abdullah M. Asiri and Siva S. Panda*   Pages 67 - 84 ( 18 )


Background: Microwave irradiation has emerged as a useful synthetic strategy for chemists and drug developers due to enhanced yields, regioselectivity, and faster reaction times. One area of importance in its practice has been the design of spiro compounds, which possess great interest on account of their natural occurrence and medicinal capabilities. The increasingly large number of these scaffolds and unlimited amount of methodologies utilized in their preparation have made them good candidates for the microwave assisted approach.

Conclusion: Therefore, this review emphasizes the use of microwave irradiation in the synthesis of spiro heterocyclic compounds.


Spiro compounds, heterocycles, microwave, green synthesis.


Acharya Narendra Dev College, University of Delhi, Govindpuri, Kalkaji, New Delhi-110019, Guru Gobind Singh Indraprastha University, Sector-16 C, Dwarka, New Delhi-110078, Department of Chemistry & Physics, Augusta University, Augusta, Georgia 30912, Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Department of Chemistry & Physics, Augusta University, Augusta, Georgia 30912

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