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Recent Synthetic Approaches to N,N-Dimethyl-β-Ketoenamines

[ Vol. 21 , Issue. 21 ]

Author(s):

Hatem M. Gaber*, Zeinab A. Muhammad, Sobhi M. Gomha*, Thoraya A. Farghaly and Mark C. Bagley   Pages 2168 - 2195 ( 28 )

Abstract:


Background: N, N-dimethyl-β-ketoenamines have proven to be of biological interest and provide an access to new class of biologically active heterocyclic compounds for biomedical applications.

Objective: It is substantial and very helpful for the scientific researchers,interested in the chemistry of enaminones to collect all methods for the preparation of different types of enaminones in one review.

Conclusion: This review provides an up to date information about the recent progress in synthetic approaches to N, N-dimethyl-β-ketoenamines, mainly using N, N-dimethylformamide dimethylacetal (DMF-DMA) as an efficient β-(dimethylamino)methylenating agent. The bibliography includes 166 references which have been published during the period from 1998 to the mid of 2017.

Keywords:

N, N-dimethylenamino-ketones, DMF-DMA, condensation reactions, addition reactions, geometrical isomers, synthetic approaches.

Affiliation:

National Organization for Drug Control and Research (NODCAR), P.O.Box 29, Cairo, National Organization for Drug Control and Research (NODCAR), P.O.Box 29, Cairo, Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt and National Organization for Drug Control and Research (NODCAR), P.O. Box 29, Cairo, Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Department of Chemistry, University of Sussex, School of Life Sciences, Falmer, Brighton, East Sussex, BN19QJ

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