Esmail Vessally*, Mirzaagha Babazadeh, Akram Hosseinian, Ladan Edjlali* and Lakshmaiah Sreerama* Pages 199 - 205 ( 7 )
β-lactams have attracted a significant attention due to their potential biological activities and wide variety of synthetic applications. Developing novel and efficient methods for construction of functionalized β-lactams has been the subject of a number of papers in recent years. N-Propargyl amines/amides are one of the most specific class of alkynes having diverse reaction patterns. It is well known that they can undergo a number of cyclization reactions to produce various significant nitrogen containing heterocycles. This review surveys literature methods for the synthesis of highly substituted β-lactams from simple and easily available N-propargyl amine/amide derivatives from 1991 to 2017.
β-lactams, N-propargylamines, N-propargylamides, 4-exo-dig cyclization, Ugi-adducts, carbon monoxide.
Department of Chemistry, Payame Noor University, Tehran, Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Department of Engineering Science, College of Engineering, University of Tehran, P.O. Box 11365-4563, Tehran, Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Department of Chemistry and Earth Sciences, College of Arts and Science, Qatar University, P.O. Box 2713, Doha