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Recent Advances in Synthesis of Functionalized β-Lactams through Cyclization of N-Propargyl Amine/Amide Derivatives

[ Vol. 22 , Issue. 2 ]

Author(s):

Esmail Vessally*, Mirzaagha Babazadeh, Akram Hosseinian, Ladan Edjlali* and Lakshmaiah Sreerama*   Pages 199 - 205 ( 7 )

Abstract:


β-lactams have attracted a significant attention due to their potential biological activities and wide variety of synthetic applications. Developing novel and efficient methods for construction of functionalized β-lactams has been the subject of a number of papers in recent years. N-Propargyl amines/amides are one of the most specific class of alkynes having diverse reaction patterns. It is well known that they can undergo a number of cyclization reactions to produce various significant nitrogen containing heterocycles. This review surveys literature methods for the synthesis of highly substituted β-lactams from simple and easily available N-propargyl amine/amide derivatives from 1991 to 2017.

Keywords:

β-lactams, N-propargylamines, N-propargylamides, 4-exo-dig cyclization, Ugi-adducts, carbon monoxide.

Affiliation:

Department of Chemistry, Payame Noor University, Tehran, Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Department of Engineering Science, College of Engineering, University of Tehran, P.O. Box 11365-4563, Tehran, Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Department of Chemistry and Earth Sciences, College of Arts and Science, Qatar University, P.O. Box 2713, Doha

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