Gamal A. El-Hiti, Keith Smith and Amany S. Hegazy Pages 585 - 598 ( 14 )
Traditional Friedel-Crafts acylation reactions of aromatics suffer from low regio-selectivity towards para- or more linear isomers and usually require stoichiometric quantities of Lewis acids, which are hydrolysed to produce toxic waste during aqueous work-up. Zeolites can catalyse and enhance the selectivity in Friedel-Crafts acylation reactions of simple aromatics and heterocycles. For example, high regioselectivity was achieved in acylation of aromatic ethers, aromatic hydrocarbons and heterocycles over zeolites. This brief review highlights the importance of zeolites to enhance the regioselectivity in Friedel-Crafts acylation reactions.
Acylating reagents, aromatics, Friedel-Crafts acylation, heterocycles, regioselective, zeolite catalysts.
Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia and School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.