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A P-Ligand-Free Nickel-Catalyzed Variation of the Hirao Reaction Under Microwave Conditions

[ Vol. 19 , Issue. 2 ]


Erzsebet Jablonkai, Laszlo B. Balazs and Gyorgy Keglevich   Pages 197 - 202 ( 6 )


The Hirao reaction, an important tool for the establishment of a P-C bond, was developed further by finding that the reaction of >P(O)H species, such as dialkyl phosphites, alkyl phenyl-H-phosphinates and diarylphosphine oxides with bromoarenes may be carried out in the presence of P-ligand-free NiCl2 as the catalyst. The scope and limitations of this “greener” approach was studied in detail.


>P(O)H species, aryl bromides, Hirao reaction, microwave, Ni-catalyst, P-ligand-free.


Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary.

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