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Recent Development in the Asymmetric Michael Addition for Carbon-Carbon Bond Formation

[ Vol. 18 , Issue. 4 ]

Author(s):

Majid M. Heravi, Parvin Hajiabbasi and Hoda Hamidi   Pages 489 - 511 ( 23 )

Abstract:


Attempts to induce stereoselectivity in the conjugate addition to the α,β-unsaturated acceptors have been investigated by numerous research groups, classically through the use of either a chiral acceptor or chiral donor component in the reaction. The asymmetric Michael addition catalyzed by chiral catalysts has been extensively proven and established to be a powerful synthetic tool for especially a range of asymmetric syntheses of natural products and various heterocyclic systems.

This review covers the recent reports and further applications of this methodology in the formation of carbon-carbon bond between or within functionalized and sensitive substrates which provides new opportunities, mainly in the total synthesis, medicinal and process chemistry, nanotechnology and chemical biology.

Keywords:

Asymmetric conjugation, C-C bond formation, chiral reagent, chiral catalyst, enolizable carbonyl derivatives, Michael addition.

Affiliation:

Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran, Iran.



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