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(+)-3-Carene: Valuable Starting Material for Synthesis of Low-molecular Compounds with Olfactory Properties

[ Vol. 18 , Issue. 4 ]


Daniel Strub, Lucyna Balcerzak and Stanislaw Lochynski   Pages 446 - 458 ( 13 )


In this article we present (+)-3-carene as a valuable source for the synthesis of compounds with various odoriferous properties. Described compounds consist of carane, bicyclo[3.1.0]hexane, and gem-dimethylcyclohexane system in their structure. Olfactory comparative analysis with regard to the structure has been discussed. Fragrance of molecules varies from different fruit notes to floral and woody. Future prospects regarding application of biocatalysts towards synthesis of compounds with olfactory properties are briefly discussed and the synthesis details are also presented to show the simplicity of the preparation of some valuable fragrant molecules. The major part of our study has been previously described only in patents that in our opinion makes this paper a valuable data source of olfactory characteristics of low-molecular compounds derived from (+)-3-carene.


(+)-3-carene, fragrance, olfactory evaluation, carane system, bicyclo[3.1.0]hexane, gem-dimethylcyclohexane.


Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland and Institute of Cosmetology, Wroclaw College of Physiotherapy, Kosciuszki 4, 50-038 Wroclaw, Poland.

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