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Michael Addition-initiated Sequential Reactions from 1,3-dicarbonyls for the Synthesis of Polycyclic Heterocycles

[ Vol. 17 , Issue. 18 ]

Author(s):

Xavier Bugaut, Damien Bonne, Yoann Coquerel, Jean Rodriguez and Thierry Constantieux   Pages 1920 - 1928 ( 9 )

Abstract:


This review aims to highlight the most significant recent developments on synthetic strategies involving consecutive, domino and multicomponent reactions featuring a Michael addition-initiating step for the synthesis of polycyclic heterocycles from 1,3- dicarbonyls. These original sequences constitute more efficient and eco-compatible alternatives to known synthetic approaches to heterocyclic compounds allowing for an even faster and highly desirable generation of molecular diversity and complexity.

Keywords:

Consecutive reactions, Domino reactions, Multicomponent reactions, Michael addition, Polycyclic heterocycles, 1, 3-Dicarbonyl compounds.

Affiliation:

Aix Marseille Universite, CNRS, iSm2 UMR 7313, 13397, Marseille, France.



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