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Gating in Host-Guest Chemistry

[ Vol. 17 , Issue. 14 ]

Author(s):

Fang Liu, Hao Wang and Kendall N. Houk   Pages 1470 - 1480 ( 11 )

Abstract:


Gating in host-guest chemistry refers to conformational changes that occur in response to some stimulus, resulting in opening or closing of a physical barrier that controls access to the host. Gating due to conformational changes of protein loops is common in enzyme catalysts: the binding of a substrate in an enzyme often involves the closing of a protein loop to bind the substrate, a type of gating [1]. Cram’s pioneering work in host-guest chemistry led to the discovery of one molecule inside another and the concept of container molecules. Cram’s nanometer-scaled container molecules were found by our group to involve gating to allow passage of guest molecules into or out of the container host [2]. The gating process in container molecules provides a novel way that binding and release of guest molecules can be controlled, and this has potential applications in controlled drug delivery.

Keywords:

Gating, Host-guest chemistry.

Affiliation:

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, 90095-1569, USA.



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