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Click-Chemistry in Biocatalysis

[ Vol. 17 , Issue. 7 ]

Author(s):

Jose M. Palomo   Pages 691 - 700 ( 10 )

Abstract:


The application of specific chemical strategies to alter the structure of enzymes in order to improve their catalytic properties in different biotransformations has been a central role in biocatalysis in recent years. Particularly, cycloaddition reactions have represented a successfully methodology for enzyme chemistry because it is chemoselective and extremely rate-accelerated in aqueous media. Some of the most current examples in the use of click chemistry for site-specific modification and immobilization of enzymes has been reviewed in the present article.

Keywords:

1, 3-dipolar cycloaddition, Diels-Alder reaction, chemical modification, biocatalysis, biotransformations, selectivity, chemoselectivity, enatioselectivity.

Affiliation:

c/Marie curie 2, Cantoblanco, campus UAM, 28049 Madrid, Spain.



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