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One-Step Synthesis of 1,2,5-Trisubstituted Pyrroles by Copper Catalyzed Condensation of 1,4-Diones with Primary Amines

[ Vol. 16 , Issue. 20 ]


Rapelli Srinivas, Boningari Thirupathi, J. K. Prashanth Kumar, Avvari N. Prasad and Benjaram M. Reddy   Pages 2482 - 2489 ( 8 )


Highly dispersed copper iodide on activated carbon (CuI/C) solid catalyst has been investigated for the Paal–Knorr condensation of γ-diketones with aliphatic, aromatic and heterocyclic amines under solvent-free conditions; which lead to the formation of N- substituted pyrrole derivatives in excellent yields. This simple experimental procedure combined with easy recovery and reusability of the catalyst is expected to contribute to the progression of a clean and ecofriendly strategy for the synthesis of N-substituted pyrrole derivatives.


CuI/C, Heterogeneous catalyst, Paal–Knorr condensation, N-Substituted pyrroles, Solvent-free, Montmorillonite, anhydrous Na2SO4, N-substituted pyrroles, substituents, hexadecylamine.


Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Uppal Road, Hyderabad–500 607, India.

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