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Towards Development of Novel Chitosan Based Drug Delivery Prototypes: Devices for Targeted Delivery Drug Therapy at the Molecular Level in Aqueous Media

[ Vol. 16 , Issue. 20 ]

Author(s):

Victoria T. Perchyonok, Shengmiao Zhang and Theunis Oberholzer   Pages 2437 - 2439 ( 3 )

Abstract:


We recently showed that chitosan containing hydrogel isare capable of displaying antioxidant activity and prevents formation of oxidative DNA damage in vitro [9].

In this short communication we report our investigations towards developing two alternative novel simple flexible and effective drug delivery systems that provide optimal dosage of drugs precisely where and when needed and therefore achieve and sustain a complex delivery profile. Two topics of a. free radical generation in biocompatible media and b. supramolecular host-guest recognition through miniaturizing and multi-functionalizing molecular carriers for improved drug delivery in disease-specific manner are combined with the aim of harnessing free radical reactivity within the laboratory and developing alternative and effective treatments for disease states mediated by free radicals.

Keywords:

Free radicals, chitosan, drug delivery systems, host-guest chemistry, aqueous media, cross-links, spectrophotometer, antioxidant efficiency, trichloroacetic acid.

Affiliation:

School of Dentistry and Oral Health, Griffith University, Gold Coast, Australia, 4215, VTPCHEM PTY LTD, Melbourne, 3163, Australia.



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