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McMurry Coupling of Aldehydes and Ketones for the Formation of Heterocyles Via Olefination

[ Vol. 16 , Issue. 18 ]


Majid M. Heravi and Zeinab Faghihi   Pages 2097 - 2123 ( 27 )


The low-valent titanium (LVT) reagents have gained widespread acceptance in organic synthesis since their first use in 1973. McMurry coupling reaction uses the LVT (low-valent titanium) reagents. This article is an attempt to review the broad synthetic utilizations of this reagent in inter and intramolecular coupling of carbonyl groups in olefination, resulting in the formation of heterocyclic compounds.


McMurry Coupling, Low-valent Titanium (LVT), Porphyrins, Cyclophanes, Giant Macrocycles, Five-membered Heterocycles, Seven-membered Heterocycles, Natural Products, olefination, heterocyclic.


Department of Chemistry, School of Sciences, Alzahra University, Vanak, Tehran, Iran.

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