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New Approaches to Nitrogen Containing Heterocycles: Enantioselective Organocatalyzed Synthesis of Dihydropyridines (DHP's), Quinolizidine Derivatives and Dihydropyrimidines (DHPM's)

[ Vol. 16 , Issue. 15 ]

Author(s):

Hoai T. Pham, Isabelle Chataigner and Jean-Luc Renaud   Pages 1754 - 1775 ( 22 )

Abstract:


Nitrogen-containing heterocycles, and more specifically the chiral ones, possess various biological and pharmaceutical properties. Among the approaches to these compounds, the organocatalyzed asymmetric multicomponent reaction has emerged as a powerful tool. This review will focus on the later development to chiral dihydropyridines, dihydropyrimidines and quinolizidines via asymmetric organocatalyzed synthesis....

Keywords:

Dihydropyridines, Dihydropyrimidines, Quinolizidines, Chiral Brønsted acids, Chiral thioureas, Proline type derivatives, multicomponent condensation, cyclization, chiral pocket, Bronsted acids

Affiliation:

UMR CNRS 6507 LCMT, University of Caen – ENSICAEN, Avenue du Marechal Juin, 14050 Caen (France).



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